![]() ![]() Each task also featured a non-semantic control condition: scrambled pictures and reversed speech, respectively. ![]() ![]() We evaluated the cortical structure and dynamics of the lexical semantic network in driving speech production in a large cohort of patients with epilepsy using electrocorticography ( n = 64), functional MRI ( n = 36), and direct cortical stimulation ( n = 30) during two generative language processes that rely on semantic knowledge: visual picture naming and auditory naming to definition. This limitation in our understanding of semantic memory has impeded progress in the treatment of anomia. Such a network hub has been proposed by others, but has thus far eluded precise spatiotemporal delineation. ![]() We hypothesize that inputs to the semantic memory system engage a specific heteromodal network hub that integrates lexical retrieval with the appropriate semantic content. While such anomia has been well characterized by lesion symptom mapping studies, its pathophysiology is not well understood. Anomia, a disruption of semantic memory access, is the most common residual language disturbance and is seen in dementia and following injury to temporal cortex. Semantic memory underpins our understanding of objects, people, places, and ideas. ![]()
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May 2023
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